Complexes of ferromagnetic fluids with photoditazin and their promising applications in photodynamic therapy
Authors:
Yu.V. Kulvelis, V.A. Trunov, V.T. Lebedev, D.N. Orlova, D. Torok, M.L. Gelfond
Authors from CMD:
The year of the publication:
2009
Journal:
Journal of Structural Chemistry
N 5
vol. 50
949-953
Keywords:
photodynamic therapy (PDT), photoditazin, magnetic fluids, neutron scattering
Abstract:
Nanosized complexes of ferroparticles with a sensitizer photoditazin (used in photodynamic therapy in oncology) have been synthesized and studied by small-angle neutron scattering. The structure of the complexes was determined, and the influence of the biocompatible polymer pluronic investigated. Clinical tests revealed increased efficiency of the complexes compared with the starting photoditazin. The complexes can be used as the first magnetically operated sensitizer for treatment of oncological diseases by photodynamic therapy.