Structure of magnetically guided nanocarriers of the Photodithazine sensitizer from small-angle neutron scattering data

Authors:
Yu. V. Kulvelis, V. A. Trounov, V. T. Lebedev, D. N. Orlova, Gy. Török, M. L. Gelfond
The year of the publication:
2010
Journal:
Physics of the Solid State N 5 vol. 52 1040-1044
Keywords:
Pluronic, Magnetic Fluid, Scatter Cross Section, Small Angle Neutron Scattering, Magnetite Particle
Abstract:

Nanosized complexes of ferromagnetic particles with a photodithazine sensitizer (used in photodynamic therapy in oncology) have been synthesized and investigated using small-angle neutron scattering for the first time. The structure of the complexes has been determined, and the influence of the biocompatible polymer Pluronic on their structure has been analyzed. The possibilities of using the complexes for magnetically guided delivery of the photosensitizer to cells and tissues in the treatment of oncological diseases by photodynamic therapy have been discussed.

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