Polymer hydrogels with the memory effect for immobilization of drugs
Authors:
V. N. Pavlyuchenko, S. S. Ivanchev, O. N. Primachenko, S. Ya. Khaikin, V. F. Danilichev, V. S. Proshina, V. A. Trunov, V. T. Lebedev, Yu. V. Kul’velis
Authors from CMD:
The year of the publication:
2011
Journal:
Polymer Science Series A
N 4
vol. 53
323 - 335
Keywords:
Memory Effect, HEMA, Small Angle Neutron Scattering, DMAEMA
Abstract:
Hydrogels with the memory effect are synthesized from crosslinked copolymers of 2-hydroxyethyl methacrylate and functional monomers (acrylic acid or dimethylaminoethyl methacrylate) via the method of template synthesis with the use of the drug cephazoline as a matrix. It is shown that the hydrogels show an increased sorption activity against the target drug and a slow rate of drug release from the hydrogel (the memory effect) under certain conditions. In combination with cephazoline, these hydrogels may be regarded as a new prolonged-drug-release system for the treatment of infectious diseases.