In this chapter, we postulate an integral concept of information processing in the universe, on the basis of a new biophysical principle, coined the generalized music (GM)-scale of EMF frequencies. Meta-analyses of current biomedical literature revealed the presence of a distinct pattern of discrete EMF frequency bands in a wide range of animate and non-animate systems. The underlying algorithm of harmonic solitonic waves provided a novel conceptual interface between living and non-living systems being of relevance for the areas of brain research as well as biological evolution. We hold that nature is guided by resonating quantum entities related to quantum vacuum fluctuations of an imminent zero-point energy (ZPE) field, also regarded as a superfluid quantum space (SQS). Since the whole human organism, including the brain is embedded in this dynamic energy field, a pilot wave guided supervenience of brain function is conceived. Conversely, the brain may write discrete informational states into the ZPE field as individual memory traces. Both information fluxes may be related to a holofractal memory workspace, associated with, but not reducible to the brain, that operates as a scale-invariant mental attribute of reality. Our concept, therefore, addresses the earlier postulated “hard problem” in consciousness studies. The proposed field-receptive workspace, integrates past and (anticipated) future events and may explain overall ultra-rapid brain responses as well as the origin of qualia. Information processing in the brain is shown to be largely facilitated by propagation of hydronium (proton/water) ions in aqueous compartments. The hydronium ions move freely within a hexagonally organized H2O lattice, providing a superconductive integral brain antenna for receiving solitonic wave information according to the Schr?dinger wave equation. The latter quantum process enables an ultra-rapid soliton/biophoton flux that may orchestrate overall brain binding and the creation of coherent conscious states. In a cosmological context, we envision a scale-invariant information processing, operating through a toroidal/wormhole operator at the interface of our 4D world and acoustic phase space. We submit that the resulting meta-language is instrumental in a partially guided evolution and the creation of first life. The central message provided here describes intrinsic cosmic connectivity that is mirrored in the human brain. This implies that sentience exists on infinite scales, on the basis of an electromagnetic signature of the universe which reveals a musical master code.