Novel biocompatible Cu2+-containing composite hydrogels based on bacterial cellulose and poly-1-vinyl-1,2,4-triazole

Authors:
Ruslan Yu. Smyslov, Gennady P. Kopitsa, Yu E. Gorshkova, Ksenia V. Ezdakova, Albert K. Khripunov, Alexandra V. Migunova, Natalia V. Tsvigun, Svetlana A. Korzhova, Artem I. Emel'yanov, Alexander S. Pozdnyakov
The year of the publication:
2022
Journal:
Smart Materials in Medicine vol. 3 382 - 389
Keywords:
Cellulose composite, Bacterial cellulose, Supramolecular structure, poly(1-vinyl-1,2,4-triazole), SANS, USANS
Abstract:

Novel composite hydrogels representing interpenetrating polymeric networks (IPN) have been synthesized and consisted of Gluconacetobacter xylinus cellulose (GxC) and poly-1-vinyl-1,2,4-triazole (PVT) with Cu2⁺. The composite hydrogels’ mesostructure has been studied from 1.6 nm to 2.5 μm by small-angle and ultra-small-angle neutron scattering methods. It has been found that IPN complexes have three types of inhomogeneities: GxC, PVT, and its complex with Cu2⁺. The amount of the absorbed ions can be tuned as confirmed by electron paramagnetic spectroscopy. Besides, three hierarchy levels of GxC remained in the supramolecular structure of composite hydrogels. Reveling structure formation in these composite hydrogels is essential in fabricating hybrid polymeric materials for regenerative medicine, involving antibacterial or antifungal applications.

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